Top 10 Best Hypoallergenic Mattress Covers Reviewed for 2022
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Over 50 million Americans suffer from allergies each year. If you or a family member suffer from allergies you know how challenging it can be to deal with. If you have tried coping with allergies and cleaning your home regularly but still suffer from them your mattress may be the culprit.
Mattresses are one of the leading sources of allergies in the home. Many people do not realize that all mattresses can hold a variety of dust mites, bugs, allergens, and even dead skin cells. We use sheets to help protect our mattresses, but this does not keep all of the allergens out of our beds.
One of the only ways to truly protect your mattress and keep you and your family safe from allergies is to use a hypoallergenic mattress cover. These covers can zip up your mattress and keep it safe from all allergens.
Since most of us spend nearly eight hours a day in our beds it is crucial that we all take the necessary steps to protect our beds and ourselves from getting sick.
So What is the Best Allergy Mattress Cover?
A hypoallergenic mattress cover protects you from the allergens that live on and in their mattress. While many of us may think that mattresses are safe from these allergens because the mattress is not old, this is not true.
These allergens are invisible to the naked eye and therefore are very difficult to clean and get rid of. A hypoallergenic mattress cover provides an additional level of protection against the contact that a person has with a mattress.
This additional level of security can reduce your contact with the mattress which can significantly reduce and even rid you of your allergy symptoms and help you sleep better each night. If you have pets a mattress cover is an additional level of security that you can take to avoid sleeping on pet hair and dander.

Many people who suffer from allergies often find themselves waking up in the middle of the night with a cough, sneeze, runny nose, watering eyes, and a variety of other symptoms. Using a mattress cover and washing it frequently can leave you feeling rejuvenated each morning.
Mattress covers also provide additional benefits that can keep your home safer and healthier for your entire family. The best mattress covers will often be waterproof, noiseless and allergen proof. The ones that are covered on all six sides of the mattress will also be bed bug proof.
Types of Hypoallergenic Covers
Hypoallergenic mattress covers can either be Fitted, Zippered or Top-Only. The fitted mattress cover protects the top sleeping surface of the mattress and the 4 adjacent sides only. The zippered ones cover the top, bottom and all the four sides of the mattress.
The zippered mattress covers provide the maximum protection and are also referred to as mattress encasements. They are better if you also want to protect the mattress against bed bug infestations. The top-only types are the most basic and and only cover the top of the mattress.
The most common materials used for mattress covers are:
- Vinyl
- Polypropylene
- Cotton
- Stretched polyester
Vinyl is waterproof and retards fire while polypropylene is not as noisy as vinyl. But note that vinyl is not beathable so without a good airflow design, such mattress covers may heat up of slept on. Stretched polyester is the most durable and versatile. Cotton is organic, breathable and soft to sleep on, but it is not waterproof.
If you are looking for the optimal way to reduce your allergies, read on to see our picks for the best hypoallergenic mattress covers available today. Our selections are based on verified customer and owner experiences, as well as intensive product research and analysis.
PRODUCT | DETAILS | RATING |
---|---|---|
SafeRest | ||
Hospitology Products | ||
Linespa | ||
National Allergy | ||
Utopia Bedding |
OUR #1 RATED - SafeRest
The SafeRest Premium Hypoallergenic Mattress Cover is a breathable mattress protector that covers the top and sides of your mattress. It is offered in a variety of sizes to fit any bed. This mattress cover is machine washable so you can clean it regularly.
It is also protects you and your family from dust mites, allergens and bacteria. The mattress cover is waterproof so it is great for young children who may still wet the bed. The waterproof feature of this mattress cover can ensure that your mattress is protected from unpredictable spills. It can keep your mattress safe and clean.
This cover is vinyl free, so it is breathable and noiseless. It has a soft cotton terry surface which enables the quietness and which helps to keep you cool. You will not have to hear the ruffling around of the cover when you move in your sleep.
SafeRest also offers a 10 year warranty on the mattress cover to ensure that your investment is protected. To get the zippered bed bug proof version of this hypoallergenic mattress cover that covers all the six sides of the mattress, click here.
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RUNNER UP - Hospitology Products
The Hospitology Products Sleep Defense System Zippered Mattress Encasement is a great option if you are looking for a breathable hypoallergenic mattress cover that does not trap heat and comletely covers the mattress on all sides.
This zippered mattress cover will help you get more relief if you suffer from asthma or if you have respiratory allergies. It will help reduce the amount of allergens that you are exposed to while you sleep.
The mattress encasement is also bed bug proof and protects against dust mites so your mattress, family, and home are safe from these annoying pests. It is waterproof and made from polyester knit fabric to protect your mattress from any fluids.
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Best Value - Linespa
The Linespa Zippered Hypoallergenic Breathable Mattress Cover is an effective mattress cover that comes with a significant amount of benefits. This mattress cover uses zippered technology to ensure a secure fit in almost all mattress.
The zipper also prevents bed bugs from moving in between the boundary of the mattress cover. This mattress cover is great for those who suffer from allergies because it is hypoallergenic and creates a boundary that dust mites and bacteria cannot penetrate. This mattress cover is offered in a variety of sizes to fit almost any mattress.
This breathable mattress protector is waterproof and hence prevent water or other fluids from getting onto the mattress. You will thus not have to worry about young children wetting the bed or spilling fluids onto the mattress.
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Best Luxury - National Allergy
The National Allergy hypoallergenic mattress protector helps protect your home, bed, and family from bed bugs, dust mites, and other allergens. This mattress cover can help get your allergies under control and leave you feeling more rested each morning.
This fully zipped allergy control mattress cover does not shrink after being washed and also maintains the size of its breathable pores. The six -sided cover features a zippered system to help prevent allergens and pests from breaking the boundary between the bed and people.
It is made of 300 thread count 100% cotton to ensure a more comfortable sleep without noise. It is made in the United States but note though that it will be difficult to fit over a latex mattress due to the cover's shape and the firm texture of latex rubber.
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Best Eco-Friendly - Utopia Bedding
The Utopia Bedding Bamboo Fitted Mattress Cover is made of a material chemically engineered from a mixture of mainly polyester and bamboo. This material composition when used on home bedding is very effective in reducing the symptoms associated with allergies. while keeping the sleeper cool.
It has an elastic band to make it very easy to stretch it and fit in your mattress. It does not need two people to install it like some other mattress cover brands. One thing that sets this mattress apart is that if you get the right size, it does not slip and remains secure in place once installed.
The top of the mattress is protected by a breathable thermoplastic polyurethane membrane that is also waterproof so that you will not have to worry about sweat or other fluids ruining your mattress.
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#6 - PlushDeluxe
The PlushDeluxe Premium Zippered Mattress Encasement uses a zippered design to fit snuggly around your mattress. It fits mattresses 9 to 12 inches deep and has a very thin breathable layer that permits air flow but which at the same time prevents liquids seeping through.
It is therefore fully waterproof and also bed bug and dust mite proof. Unwanted pests have no way in or out as it is covered on all of its six sides, with only a velcro covered zipper offering a way to access the mattress. Most importantly, this mattress cover is hypoallergenic and features a cotton terry surface for a more cool & comfortable night's sleep.
You might be surprised after using it as it is quiet and doesn't make any crinkly plastic noises. This is because of the cotton terry and the fact that there is no PVC or vinyl. This mattress protector can really help people suffering from asthma, eczema, and other allergies.
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#7 - Lucid Allergen Proof Encasement Mattress Protector
This hypoallergenic mattress cover from Lucid comes with a watertight zipper and sealing bug flap. It is made of 100% polyester and has a waterproof zipper that ensures complete protection from dust mites, liquid spills, stains, and allergens.
The encasement mattress protector offers quiet, breathable comfort which reduces the risk of re-breathing and improves airflow while keeping away bedbugs.
The hypoallergenic fabric is smooth, soft, comfortable, and produces no crinkling sound, enabling one to sleep very soundly. Also, the mattress cover has deep pockets that stay put and fit more comfortably. This helps one spend less time in making their bed.
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#8 - Luna Premium Hypoallergenic Waterproof Mattress Cover
The Luna Premium Hypoallergenic 100% Waterproof Fitted Mattress Protector cover is made of natural soft cotton terry and an additional hypoallergenic, breathable, and waterproof layer. On account of this, the cover offers full mattress protection against allergens like dust, fungi, pollen, perspiration, and spilled fluids including urine.
This helps maintain a clean mattress until the cover can be machine laundered. This should be done on a quarterly basis without the use of bleach. Ironing should also be avoided since it can compromise the quality of the material.
The cover is available in all standard bed sizes and has an elastic band on the side skirt which guarantees a perfect fit, with all excess fabric tucked underneath the mattress for a good night’s sleep. Note that the the cotton terry surface has great absorbtion and cooling properties and that this mattress protector cover has no vinyl or PVC.
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#9 - SureGuard
This mattress encasement from Sureguard comes in a premium 6-sided cover with a concealed zipper for easy removal. It is made of a 100% waterproof, hypoallergenic cotton terry top that protects the underlying mattress from spilled drinks, bedwetting, mites, dust, mold, allergens, and even perspiration.
The additional zipper ensures the cover totally engulfs the mattress, thereby keeping away bed bugs too. The zipper is designed using the Invisi-Zip installation and also uses SureSeal technology to ensure no bed bugs sneak through the zipper.
The cotton terry top material is soft, cool and comfortable to lie on with added advantage of it being noiseless even when tossing and turning during the night. When it comes to cleaning, the encasement should be machine washed and dried, as frequently as the user prefers.
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#10 - Sable Fitted Mattress Cover
The Sable Waterproof Protector Breathable Mattress Pad Cover with Elastic Band comes in a 5-sided cloth with some supportive elastic bands. It is made of a 100% waterproof membrane, and an 80% Cotton Terry Surface, with the rest of the 20% being polyester.
This makes the material ultra-thin and ultra-light which, in turn, makes it quite breathable, ensuring enough air circulation in the mattress even when the bed is occupied. The cover is normally fitted onto the mattress like a sheet and has elastic bands for extra support. These ensure that the mattress fits perfectly and remains wrinkle-free even after sleeping on it.
It also easy to clean using bleach-free products in a laundry machine. Dry Cleaning ironing could, however, damage the material and should be avoided. Additionally, this cover has been registered with the FDA as A Class 1 Medical Device. Despite this, the cover’s liner flakes over time due to continued wear and tear, which creates a poor visual image.
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#11 - TRU Lite Bedding
This hypoallergenic fitted mattress cover from TRU Lite is made of 100% cotton. This material is very soft and comfortable to lie on and does not change the feel of the bed. It also has waterproof protection that locks out the stain, sweat, odors, spills from drinks, and urine.
The TRU Lite Bedding Hypoallergenic Mattress Cover ensures protection from allergens like dust and mites. When it comes to washing, no fabric softener or bleach is used, and it should also be machine washed and dried.
Additionally, the cover has deep pockets that allow it to stretch over thick mattresses, enabling one to spend less time making their bed.
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#12 - PlushDeluxe Premium Bamboo Fitted Mattress Cover
This mattress cover is made from the finest quality, natural bamboo fabric, and an additional breathable membrane that regulates heat creating a fresh and cool sleeping environment.
It is ultra-soft and is made of 100% waterproof and hypoallergenic material that offers protection from liquid spills, wear and tear, dirt, and dust mites. This ensures the mattress stays clean and comfortable for a long time.
The PlushDeluxe Premium Bamboo Fitted Mattress Cover is suitable for different mattress designs including spring, memory foam, latex and hybrid mattresses. It doesn't contain vinyl so you will not have your sleep disturbed by any crinkly plastic noises as you toss & turn during the night,
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FINAL THOUGHTS

If you or someone in your family suffers from allergies you should highly consider investing in a hypoallergenic mattress cover. They create a barrier between you and the mattress while you sleep.
This barrier helps reduce your exposure to allergens, which inhibit your ability to sleep and affect your overall health and wellbeing. Using an allergy mattress cover can leave you feeling more rested each night and give all the benefits that go with that from improved body immunity to better brain & reproductive functions.
While each one of these mattress protectors come with their own different benefits and unique points, but our best overall is the SafeRest Hypoallergenic Zippered Mattress Cover. This mattress cover is completely waterproof, allergen proof, and bed bug proof. It can prevent damage to your mattress, increase the overall lifespan of your mattress, and reduce the symptoms of allergies that you or your family may experience.
This mattress cover is also noiseless and includes a long warranty. If you are looking for a solution to your allergies and restless nights, you should highly consider looking into the SafeRest Mattress Cover.

He is an Engineer, designer and jogging enthusiast. His team of product testers and reviewers are as passionate as he is about sleep improvement and are on a collective mission to reveal to you only the best sleep solutions and products.